Abstract
Evidence that the liver destroys the activity of oestrogens has been strongly presented in a long list of publications and there appears to be no serious dissenting opinion [Cantarow, Rakoff, Paschkis, Hansen & Walkling, 1943]. The inactivation of oestrogens by isolated liver tissue is one of the clearest demonstrations of this hepatic function [Silberstein, Engel & Molnar, 1933; Heller, 1940; Engel, 1941]. It should also be recalled that Golden & Sevringhaus [1938] implanted ovaries in the mesenteries of rats without producing oestrus; that Biskind [1941] failed to obtain atrophy of the reproductive organs of male rats when pellets of oestrone were implanted into the spleen but that atrophy resulted when the implants were made subcutaneously; and that damage to the liver favours higher concentrations of oestrogens in blood [Talbot, 1939; Pincus & Martin, 1940] and in urine [Glass, Edmondson & Soil, 1940]. Cantarow, Rakoff, Paschkis & Hansen [1942] gave evidence
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