Abstract

Objective: To determine whether patients with an abnormal sugar permeability test, but with normal jejunal biopsy specimens on routine histology, have alterations in their enterocyte dimensions. Design: We examined histological sections of jejunal biopsy specimens from normal subjects, patients with coeliac disease, and subjects with «normal» biopsy specimens, but with an abnormal cellobiose/mannitol test (the'test'subjects). Method: Enterocyte dimensions were measured using an eyepiece micrometer at standard magnification. Six measurements of cell height were made for each of four compartments of the mucosa, comprising upper, middle, and lower thirds of the villi, and the crypt, in normal and test subjects, and from crypt and surface enterocytes in coeliac patients

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