Abstract
Abstract Glioma is the most common primary central nervous system tumor. The World Health Organization (WHO) 2021 classification of gliomas extended from WHO 2016 in the integration of molecular and histological classifications. WHO 2021 aims to establish a specific diagnosis that could reflect the biological and clinical features of the tumors, and further transform into more specific clinical studies or trials and therapeutics. Major updates of WHO 2021 classification focusing on glioma were reviewed in this article.
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