Abstract
Four new ent-abietane diterpenoids, along with four known ones were isolated from the aerial parts of Isodon serra, a traditional Chinese folk medicine. The new diterpenoids were named as serrin K (1), xerophilusin XVII (2), and enanderianins Q and R (3 and 4), while the known ones were identified as rubescansin J (5), (3α,14β)-3,18-[(1-methylethane-1,1-diyl)dioxy]-ent-abieta-7,15(17)-diene-14,16-diol (6), xerophilusin XIV (7), and enanderianin P (8), respectively. Their structures were elucidated by extensive spectroscopic analysis and comparison with the literature. Compound 1 showed remarkable inhibitory activity towards NO production in LPS-stimulated RAW264.7 cells (IC50 = 1.8 μM) and weak cytotoxicity towards five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480).
Highlights
The perennial plant Isodon serra (Maxim.) Hara, belonging to the Lamiaceae, has long been used as Chinese folk medicine for the treatment of jaundice hepatitis, acute cholecystitis, and enteritis [1,2]
Due to the excellent anti-tumor and anti-inflammatory effects of diterpenoids isolated from I. serra [14,15,16,17,18,19,20,21,22] and its wide use towards hepatitis and cholecystitis in Chinese folk medicine, some of the isolates have been assayed for their anti-tumor effects against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480), as well as the inhibitory activity of NO production in LPS-stimulated RAW264.7 cells
The human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW-480 were used, which were obtained from ATCC (Manassas, VA, USA)
Summary
The perennial plant Isodon serra (Maxim.) Hara, belonging to the Lamiaceae, has long been used as Chinese folk medicine for the treatment of jaundice hepatitis, acute cholecystitis, and enteritis [1,2]. Due to the excellent anti-tumor and anti-inflammatory effects of diterpenoids isolated from I. serra [14,15,16,17,18,19,20,21,22] and its wide use towards hepatitis and cholecystitis in Chinese folk medicine, some of the isolates have been assayed for their anti-tumor effects against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480), as well as the inhibitory activity of NO production in LPS-stimulated RAW264.7 cells.
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