Abstract
In present study, the performance and separation characteristics of 21 macroporous resins for the enrichment and purification of deoxyschizandrin and γ-schizandrin, the two major lignans from Schisandra chinensis extracts, were evaluated. According to our results, HPD5000, which adsorbs by the molecular tiers model, was the best macroporous resin, offering higher adsorption and desorption capacities and higher adsorption speed for deoxyschizandrin and γ-schizandrin than other resins. Columns packed with HPD5000 resin were used to perform dynamic adsorption and desorption tests to optimize the technical parameters of the separation process. The results showed that the best adsorption time is 4 h, the rate of adsorption is 0.85 mL/min (4 BV/h) and the rate of desorption is 0.43 mL/min (2 BV/h). After elution with 90% ethanol, the purity of deoxy-schizandrin increased 12.62-fold from 0.37% to 4.67%, the purity of γ-schizandrin increased 15.8-fold from 0.65% to 10.27%, and the recovery rate was more than 80%.
Highlights
Fructus Schisandrae Chinensis, the dried fruit of Schisandra chinensis (Magnoliaceae) is one of the most famous and frequently used herbal medicines and food additives
Various reports have suggested that major bioactive constituents of S. chinensis are deoxyschizandrin (DS) and γ-schizandrin (GS) [11,12,13]
Modern pharmacological research has demonstrated that S. chinensis shows various beneficial biological active effects, including anti-hepatotoxic, antioxidant, antitumor [14], detoxificant, anticarcinogenic [15], activity on the central nervous system and it counteracts fatigue, and increase endurance [16], has anti-inflammatory properties [17] and improves the physical performance of athletes [16]
Summary
Fructus Schisandrae Chinensis, the dried fruit of Schisandra chinensis (Magnoliaceae) is one of the most famous and frequently used herbal medicines and food additives It has a long history of medical use in China, Korea and Japan as an astringent, sedative and tonic agent to treat various diseases [1,2,3,4]. It was first recorded in the ancient pharmaceutical book “Shen Nong Ben Tsao Ching” as a superior drug and has been used for thousands of years [5]. The fruit of S. chinensis was traditionally used to alleviate or treat diseases due to deficiencies of the lungs, heart and kidneys, imbalance of Yin and Yang, and impairment of Qi [18], such as chronic cough, asthma, spontaneous sweating, palpitation, spermatorrhea, diabetes, insomnia, and forgetfulness
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