Abstract
Endoglin (CD105) is an accessory receptor for TGF-beta signaling and is required for normal hemangioblast, early hematopoietic and vascular development. We have previously shown that an upstream enhancer, Eng-8, together with the promoter region, mediates robust endothelial expression in developing embryos and when coupled with two intronic enhancers, Eng +7 and Eng +9 also targets blood clusters in the dorsal aorta, fetal liver and placenta. The hemato-endothelial activity of this composite regulatory module was also shown to be dependent on Gata and Ets binding motifs.
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