Enriched detection nanoparticles for hypochlorite prepared by electrostatic spray, applied to tumor imaging, antibacterial and antiviral

Abstract

Hypochlorite (ClO-) as a common reactive oxygen species (ROS) plays a vital role in physiological processes. However, an excessive amount of ClO- can lead to cell damage and is closely associated with the occurrence of diseases such as cancer. The high-sensitivity monitoring of intracellular ClO- is of great significance in the field of cancer diagnosis. Therefore, we have employed the electrostatic spray technology to fabricate a multifunctional nanoparticle C@B NPs and for the first time in ion sensors, proposed a method to enhance the sensitivity of sensor by increasing the electrostatic adsorption. C@B NPs can enrich ClO- onto their surface, forming a high-concentration area. It can respond better with C@B NPs, achieving enhanced sensing sensitivity, the lowest limit of detection is 1.81 nM. C@B NPs possess good anti-interference ability and biocompatibility, enabling the distinction and recognition between normal cells and cancer cells, as well as tumor imaging in live mice. Additionally, due to the large amount of quaternary ammonium salt structures in C@B NPs, they also exhibit excellent antibacterial and antiviral properties, inhibition rate bacteria and viruses against 100 %. It is first nanoparticles integrates tumor imaging, antibacterial and antiviral functions, showing potential in tumor visualization and treatment of infections.