Abstract
Theophylline and enprofylline (10-710-4M) produced concentration-dependent relaxation in sheep isolated trachealis preparations and small bronchi, under conditions of basal or carbachol-induced tone. Addition of isoprenaline (10-5M) at the end of the concentration-response curve to theophylline or enprofylline induced additional relaxation. Relaxation obtained with theophylline and enprofylline was a slow process, while the response to isoprenaline was more rapid. In all experiments under conditions of basal or carbachol-induced tone in large and small bronchi, enprofylline was 5.4–4.7 times more potent than theophylline.
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