Abstract
The moyamoya disease shows various clinical features. It is difficult to identify as specific genes associated with it are not identified yet. Although progress in the search for genetic loci underlying moyamoya disease is encouraging, a relevant specific single gene has not yet been identified. Moyamoya disease appears to be a multifactorial, polygenic disorder that does not display a classic pattern of inheritance. eNOS may be just one candidate gene among many that influence the clinical features which characterize the disease.
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