Abstract
背景与目的肺癌严重威胁人类生存健康，有效的肿瘤标志物可以辅助诊断、判断预后和指导治疗。本研究旨在检测非小细胞肺癌患者肿瘤组织和血浆中烯醇化酶1（alpha-enolase, ENO1）蛋白水平，初步探讨ENO1作为肺癌相关蛋白标志物的可能性。方法采用Western blot方法检测16例肺鳞癌患者的肿瘤组织及其配对正常肺组织中ENO1蛋白水平。采用双抗体夹心酶联免疫吸附分析（enzyme-linked immunosorbent assay, ELISA）测定42例健康体检者、34例肺部良性疾病患者和84例非小细胞肺癌患者三组人群血浆中ENO1蛋白水平。结果在87.5%（14/16）的肺鳞癌患者肿瘤组织中ENO1蛋白表达量高于其配对正常肺组织；非小细胞肺癌患者血浆中ENO1蛋白水平高于健康体检者（P=0.031）和肺部良性疾病者（P=0.019），且ENO1蛋白在肺腺癌患者血浆中的水平高于肺鳞癌患者（P=0.023）。结论非小细胞肺癌肿瘤组织和血浆中ENO1蛋白水平升高，提示ENO1可作为潜在的非小细胞肺癌相关血浆蛋白标志物。
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