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Abstract
The choroid plexus, located in brain ventricles, has received surprisingly little attention in clinical neuroscience. In morphometric brain analysis, we serendipitously found a 21% increase in choroid plexus volume in 12 patients suffering from complex regional pain syndrome (CRPS) compared with age- and gender-matched healthy subjects. No enlargement was observed in a group of 8 patients suffering from chronic pain of other etiologies. Our findings suggest involvement of the choroid plexus in the pathogenesis of CRPS. Since the choroid plexus can mediate interaction between peripheral and brain inflammation, our findings pinpoint the choroid plexus as an important target for future research of central pain mechanisms.
Highlights
The choroid plexus, located in brain ventricles, has received surprisingly little attention in clinical neuroscience
We serendipitously found a 21% increase in choroid plexus volume in 12 patients suffering from complex regional pain syndrome (CRPS) compared with age- and gender-matched healthy subjects
The choroid plexus is the key producer of cerebrospinal fluid, which provides a fluid cushion for the central nervous system and a sink for nervous-system biomarkers and debris[1,2]
Summary
The choroid plexus, located in brain ventricles, has received surprisingly little attention in clinical neuroscience. We serendipitously found a 21% increase in choroid plexus volume in 12 patients suffering from complex regional pain syndrome (CRPS) compared with age- and gender-matched healthy subjects. Our findings suggest involvement of the choroid plexus in the pathogenesis of CRPS. Using MRI, we found choroid plexus enlargement in patients suffering from complex regional pain syndrome (CRPS), a chronic and multifactorial pain disorder that initially follows a minor peripheral trauma and subsequently spreads to areas beyond the original lesion area[11,12]. The mechanisms underlying the CRPS evolvement are still poorly understood, and our findings implicating the involvement of choroid plexus in CRPS could elucidate the pathogenesis of this debilitating condition
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