Abstract
At least four peptidases are involved in the breakdown of Met-enkephalin by rat brain membranes: aminopeptidase(s), angiotensin-converting enzyme (ACE), metalloendopeptidase, and dipeptidyl aminopeptidase. Opiates and some metabolically stable enkephalin analogs used at high concentrations to displace Met-enkephalin from the receptors have no significant effect on the degradation of Met-enkephalin by these peptidases. There is no difference between the dissociation rates of Met-enkephalin from the opiate receptors in membranes, with full and with completely blocked aminopeptidase, ACE, and metalloendopeptidase activities. These data do not imply a close topographical coupling between the opiate receptors and the peptidases studied.
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