Enhancing Vaccine Efficacy and Accessibility through Microneedle Technology: A Review

Abstract

Microneedling, a minimally invasive technique involving the creation of microchannels in the skin, has emerged as a promising platform for vaccine delivery. The use of microneedles for vaccination represents a new era in immunization techniques, wherein patients no longer dread sharp pricks. Their breakthrough potential lies in their ability to deliver vaccines directly into the epidermis or dermis where a high density of immune cells improve the particularly relevant effects of vaccines. Their intro- duction has met various challenges often experienced with traditional methods like bites caused by fear, pain from needles, or even that any medical doctor may take a long to administer them. Microneedles could improve stability and lessen the dependence on cold chain transport systems since they can be prepared in dry form. In addition to providing an al- ternative to syringes, they are also considered less painful than them. The review highlights the potential of mi- croneedles to improve vaccination rates, especially in un- derserved populations, and identifies key areas for future research and development.