Enhancing tumor's skin photothermal therapy using Gold nanoparticles : a Monte Carlo simulation.

Abstract

The aim of this study is to investigate how the introduction of Gold nanoparticles GNPs into a skin tumor affects the ability to absorb laser light during multicolor laser exposure. The Monte Carlo Geant4 technique was used to construct a cubic geometry simulating human skin, and a 5mm tumor spheroid was implanted at an adjustable depth x. Our findings show that injecting a very low concentration of 0.01% GNPs into a tumor located 1cm below the skin's surface causes significant laser absorption of up to 25%, particularly in the 900nm to 1200nm range, resulting in a temperature increase of approximately 20%. It is an effective way to raise a tumor's temperature and cause cell death while preserving healthy cells. The addition of GNPs to a tumor during polychromatic laser exposure with a wavelength ranging from 900nm to 1200nm increases laser absorption and thus temperature while preserving areas without GNPs.