Abstract
Introduction Existing tissue equivalents for musculoskeletal engineering generally require days to manufacture, depending on cell activity to produce or populate scaffolding material. Plastic compression (PC) involves a rapid cellindependent expulsion of water from cellular collagen hydrogels creating mechanically stable, viable tissue sheets in a matter of minutes. This study investigated the effect of restricted PC on gels (by varying the compression type), in an attempt to produce structurally versatile collagen scaffolds compared to the current sheets/spirals, whilst retaining/improving mechanical properties and cell viability.
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