Enhancing the efficacy of depression detection system using optimal feature selection from EHR

Abstract

Diagnosing depression at an early stage is crucial and majorly depends on the clinician’s skill. The present work aims to develop an automated tool for assisting the diagnostic procedure of depression using multiple machine-learning techniques. The dataset of sample size 4184 used in this study contains biometric and demographic information of individuals with or without depression, accessed from the University of Nice Sophia-Antipolis. The Artificial Neural Network (ANN), Support Vector Machine (SVM), Random Forest (RF) and Extreme Gradient Boosting (XGBoost) are used for classifying the depressed from the control group. To enhance the computational efficiency, various feature selection algorithms like Recursive Feature Elimination (RFE), Mutual Information (MI) and three bio-inspired techniques, viz. Particle Swarm Optimization (PSO), Genetic Algorithm (GA) and Firefly Algorithms (FA) have been incorporated. To enhance the feature selection process further, majority voting is carried out in all possible combinations of three, four and five feature selection techniques. These feature selection techniques bring down the feature set size significantly to a mean of 33 from the actual size of 61 which is a reduction of 45.90%. The classification accuracy of the enhanced model varies between 84.18% and 88.46%, which is a significant improvement in performance as compared to the pre-existing models (83.76–85.89%). The proposed predictive models outperform the pre-existing classification models without feature selection and thereby enhancing both the performance and efficiency of the diagnostic process.