Abstract
Research in Medical & Engineering Sciences Enhancing Radical-Mediated Photopylomerization Efficacy and Crosslink Depth: Kinetic Modeling of a Two-Monomer System Kuo-Ti Chen1, Jui Teng Lin2 and Hsia Wei Liu3* 1Graduate Institute of Applied Science and Engineering, Taiwan 2New Vision, Taiwan 3Department of Life Science, Taiwan *Corresponding author: Hsia Wei Liu, Department of Life Science, Taiwan Submission: August 10, 2019; Published: August 27, 2019 DOI: 10.31031/RMES.2019.08.000682 ISSN: 2576-8816Volume8 Issue2
Highlights
Photopolymerization and crosslinking have been utilized in various medical and industrial applications [1,2,3,4,5]
Efficacy may be improved by additive enhancer-monomer or extended lifetime of photosensitizer triplet-state or oxygen singlet, in consistent with the measured clinical data
For a typeII process, [T] interacts with [O2] to form a singlet oxygen [O1] which could interact with [A], [B], or relaxed to [O2]. Both type-I and type-II reactions can occur simultaneously in photopolymerization and the ratio between these processes depends on the type of photosensitizer (PS) or photoinitiator (PI) used, the concentrations of PS or PI, substrate monomers and oxygen, the kinetic rates involved in the process, and the light intensity, dose, PI depletion rate etc
Summary
Photopolymerization and crosslinking have been utilized in various medical and industrial applications [1,2,3,4,5]. Tissue-engineering using scaffold-based procedures for chemical modification of polymers has been reported to improve its mechanical properties by crosslinking or polymerization with UV or visible light to produce gels or high-molecularweight polymers [3]. Industrial applications include the develop of materials for thin films, 3D bio-printing and microfabrication [4,5,6,7], in which he kinetics and mechanisms of photopolymerization have been extensively studied theoretically and experimentally [7,8,9,10,11,12,13,14,15,16]. Two-monomer systems were reported such as: (i) thiol-ene system (TES), and (ii) thiol--Michael system (TMS); where in TES, cross-linked polymer networks are formed via a two steps growth mechanism: 1. Propagation of a thiyl radical through a vinyl functional group; and
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