Abstract
Application of Quercetin (Quer) as a natural flavonoid is confined because of limited solubility in water and stability in the body. Herein, we prepared a biodegradable super paramagnetic starch-based hydrogel grafted onto fumaric acid for increasing Quer bioavailability and controlling its release. The molecular structure of starch was modified by using fumaric acid to increase hydrophilicity of hydrogel, and iron oxide nanoparticles is used to strengthen its physical and mechanical properties. The structural, morphological and magnetic properties of the optimized hydrogel were characterized. Application of the synthesized hydrogel was assessed in the in vitro and in vivo studies. In vitro release curve was nicely fitted to the Higuchi model. Stability and bioavailability of Quer were significantly increased at the plasma and liver of rats which received 100 mg kg−1 Quer- loaded on synthetic hydrogel compared with 100 mg kg−1 free Quer (p < 0.05).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
