Abstract
AbstractEffects of saturated straight-chain fatty acids at various chain lengths (C8-C18) on the permeation of indomethacin, a relatively lipophilic compound and 6-carboxyfluorescein, a hydrophilic compound were examined using rat skins in in vitro. Furthermore, the disordering degrees of intercellular lipid domain in stratum corneum, which were treated by preparation containing saturated fatty acids were measured by FT-IR method using excised rabbit ear skins. Capric acid (C10), lauric acid (C12) and myristic acid (C14) within series of saturated fatty acids (0.07 M) showed the enhancing effects on the skin permeations of indomethacin and 6-CF. The permeation enhancing effects by these saturated fatty acids (C8-C18) except for capric acid (C10), were relative to the degrees of wavenumber shift in the frequency of the asymmetric CHbond stretching absorbance (2920 cm−1) on FT-IR spectra of the fatty acid treated stratum corneum. Therefore, the perturbation increase of lipid domain in stratum corneum by the...
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