Abstract
Enhancing immunity by engineering DAMPs.
Highlights
In a recent paper [4], we have investigated and verified the possibility of engineering in plants the controlled release of damageassociated molecular patterns” (DAMPs) derived from the extracellular matrix, to enhance immune responses and confer resistance against several microbial pathogens
Our work provides direct evidence of in vivo activation of the innate immune responses upon release of DAMPs and provides a tool to investigate some important aspects of plant biology
Maintenance of immunity is costly and immune responses are typically counterbalanced by decreasing the allocation of resources to biomass production
Summary
In a recent paper [4], we have investigated and verified the possibility of engineering in plants the controlled release of DAMPs derived from the extracellular matrix (the plant cell wall), to enhance immune responses and confer resistance against several microbial pathogens. Www.impactjournals.com/oncotarget the control of a pathogen-induced promoter confers increased resistance to Arabidopsis against a variety of pathogens, pointing to a possible biotechnological use of the OG-machine to protect crop plants against a broad range of microbial diseases (Figure 1). Because the OG-machine confers resistance against both fungi and bacteria with different lifestyles, it may be useful against field and postharvest pathogens and saprophytes that cause important crop losses and mycotoxin contamination.
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