Abstract
Effects of high-fat diet on urinary bladder tumorigenesis in male Syrian golden hamsters caused by 3, 2'-dimethyl-4-aminobiphenyl (DMAB) were analyzed. DMAB was administered i. g. suspended in corn oil at a dose of 100mg/kg b. w. once a week for 20 weeks. Diet supplemented with 5% corn oil was administered throughout the experiment (50 weeks) or for 30 weeks after DMAB treatment. Incidences of DMAB-induced urinary bladder carcinomas were 27% (3/11 animals) in the basal diet group, and 58% (7/12) and 57% (4/7) respectively in the 50 and 30 week high-fat diet groups. The enhancement of bladder carcinogenesis by the high-fat diet was statistically significant by the cumulative chi-square test applied for the sequence of hyperplastic and neoplastic lesions. Thus, corn oil added to the diet increased DMAB-induced bladder carcinogenesis in hamsters.
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