Abstract
We studied the effects of taurine on the caudate spindle in rats and compared the findings with those of γ-aminobutyric acid (GABA) when these compounds were microinjected into the bilateral striatum. Three μg of taurine was without effect, whereas 10 and 30 μg of taurine enhanced the spindle in a dose-dependent manner. GABA (3–100 μg) had no significant effect. Apomorphine (0.5 mg/kg) and methamphetamine (0.5 mg/kg) given intravenously to pargyline-pretreated rats suppressed the spindle. The suppressing effects of these drugs were reduced by taurine (3 μg) at the dose which, per se, did not affect the spindle. These results suggest that taurine may decrease the activity of striatal dopaminergic neurons and enhance the caudate spindle.
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