Abstract
This study investigates the therapeutic efficacy of chitosan-based nano-scaffolds containing a quercetin-silver (QS) complex in expediting wound healing in streptozotocin (STZ)-induced diabetic rats. Synthesized through hydrothermal processes, the scaffolds were applied to epidermal wounds on the dorso-lateral region for 14 days. Extensive assessments, including morphological examinations, histopathological analyses, and evaluations of ROS scavenging, antioxidant enzyme activities, and blood biochemical parameters, were conducted post-treatment. Results unequivocally demonstrate the significant enhancement of the wound healing process, attributed to the synergistic benefits of silver's antimicrobial properties, quercetin's antioxidant capabilities, and chitosan's tissue regeneration promotion. Despite observed toxicity, likely linked to silver and quercetin's polyphenolic antioxidant properties, it did not worsen diabetic conditions. Future research aims to address potential toxicity concerns through environmentally friendly, green synthesis methods for silver nanoparticles.
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