Abstract
This study aims to evaluate the effects of pregelatinization in improving delayed release characteristics of native chapparada avare starch. Physicochemical properties and drug release characteristics were evaluated for the native and pregelatinized starches using established methods. The moisture content decreased from 12.13 ± 0.15% to 8.73 ± 0.12%, whereas amylose content (6.91 ± 0.06–21.13 ± 0.03), swelling power and water holding capacity (211.04 ± 0.03–513.03 ± 0.03) showed steady rise with pregelatinization time. The result of X ray diffraction pattern for pregelatinized starch, showed absence of 18.4° and 23.2° 2θ peaks thereby indicating reducing crystallinity, compared to native starch, whereas FESEM micrograph showed complete disruption of granular structure due to pregelatinization of native starch. The in vitro dissolution studies conducted in gastric and intestinal pH showed that tablets prepared with both native (NPL) and modified starch (PG15, PG20, PG 25), are gastro protective with less than 25% drug release in pH 1.2. In pH 6.8, PG 20 and PG 25 showed optimum drug release of 21.23 ± 0.54% and 19.40 ± 0.48% respectively in 6 h compared to 42.52 ± 0.21% release of NPL formulation, thereby indicating time based delayed drug release characteristics of over its native counterpart.
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