Enhancing dead end filtration throughput using a non-traditional liquid handling procedure

Abstract

The dead end filtration of dilute protein solutions is normally conducted with either a constant pressure or constant rate fluid delivery system. However both approaches often fall short in using all the available capacity of the filter. A novel automated fluid handling system has been recently developed by SciLog Inc, USA, which can increase the DEF yield by up to 35%. Karl Schick, director of research & development, presents and discusses throughput data supporting this claim.