Abstract
Cell‐fate transitions involve the integration of genomic information encoded by regulatory elements, such as enhancers, with cellular and signaling environments. Identification of genomic sequences that control human embryonic development represents a formidable challenge, as they are embedded within a vast noncoding genomic space. However, enhancers share certain chromatin features, including presence of specific histone modifications and general coactivators. We have recently shown that unique chromatin signatures can be used to annotate two functionally distinct classes of enhancer elements in human embryonic stem cells (hESC): active and poised. We have now extended enhancer profiling to other embryonic cell types of unusual developmental plasticity, such as the neural crest. I will discuss our new findings on the dynamics of enhancer regulation during development and on the interplay between transcription factors and chromatin modifiers involved in that process.
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