Abstract

The tumor cell susceptibility to tumor-infiltrating lymphocytes (TILs) was investigated to be augmented by pretreatment with CDDP in vitro. The susceptibility of autologous tumor cells and KATO-III cells was enhanced by treated with 2 μg/ml of CDDP for 12 h measured by 4-h and/or 16-h 51Cr-release assay. And, on that time, the binding ratio to TILs was increased, although expression of surface antigens of CDDP-treated tumor cells were not altered. Thus, it was suggested that the effect of CDDP on tumor cells susceptibility to TILs caused by the enhancement of binding to effector cells.

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