Abstract
The aim of the present study is to investigate the potential of ethosomal formulations for transdermal delivery of indinavir sulphate from ethosomes. Vesicles containing phosphatidylcholine mixed with ethanol and indinavir sulphate were prepared by conventional mechanical stirrer method and characterized by various parameters (vesicles shape and surface morphology, size and size distribution, entrapment efficiency, elasticity, turbidity and in vitro drug release). The effect of different formulation variable on skin permeation of indinavir sulphate was studied via synthetic semipermeable membrane or skin of new born mice by using diffusion cell. The selected system were incorporated into carbopol 934P gel and evaluated for both drug permeation and mice skin deposition. The optimized ethosomal formulation showed transdermal flux of 25.01±0.34 μg/cm2 /h across rat skin as compared to 2.98±0.21μg/cm2 /h for plane drug solution, 4.28±0.54 μg/cm2 /h for hydroethanolic solution and 9.7±0/21 μg/cm2 /h for classical liposomes. The obtained flux was nearly 7.5 and 12.04 times higher than conventional liposomal formulation bearing indinavir sulphate and plain drug solution. These results suggest that ethosomes are potential vehicles for improved transdermal delivery of indinavir sulphate.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
