Abstract
This study explores the formulation of self-micelle ginsenoside saponins from Panax ginseng with curcuminoids from turmeric. Although ginsenosides are hydrophilic and poorly membrane-permeable, they increase the solubility and absorption of insoluble compounds such as curcuminoids. The optimized ginsenoside-curcuminoid (GS-CUR) formulation achieved a water solubility of 2,450 µg/mL using Response Surface Methodology (RSM) at 42.9 % (v/v) water in ethanol, 389.7 mg/mL ginsenosides, and 9.06 mg/mL curcuminoids. Analytical techniques such as SEM, X-ray diffraction, and FTIR spectroscopy confirmed the presence of curcuminoids in GS-CUR. The GS-CUR complex exhibited enhanced antioxidant activities compared to free curcuminoids. Moreover, GS-CUR suppressed the release of nitric oxide in lipopolysaccharide-stimulated RAW264.7 cells by 3.77-fold and reduced lipid accumulation in 3 T3-L1 cells by 13.2-fold more than free curcuminoids. These findings suggest GS-CUR's potential as a functional material in the pharmaceutical, cosmetic, and food industries.
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