Abstract
Stimulation of antibody production has been reported in mice and rabbits only for small doses of radiation (<100 R) with antigen administration during or after irradiation. In guinea pigs, however, we have now observed enhancement with 200, 300, 400 and 500 rads. Immediately after irradiation 2 mg of rabbit gamma -globulins were given intraperitoneally and 50 mu g of ABA-Tyr (monoazobenzenearsonate-N-acetyl-L-tyrosine) in 0.1 ml of complete Freud's adjuvant in the four foot pads. Twenty days after irradiation 50 mu g of ABA-bovine serum albumin was injected intradermally and the development of delayed hypersensitivity skin reaction was followed for the next eight days. For all doses the peak of the haemagglutination titre was higher and occurred sooner than in the controls. Delayed skin reaction appeared to be slightly stimulated by 200 and 300 rads and was depressed by 400 and 500 rads. Since the LD50 of guinea pigs is 300 to 400 rads it appears impossible to achieve suppression of the primary immune response if the antigen is present shortly after irradiation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
