Abstract
□ The adenosine deaminase inhibitor pentostatin (I), recently shown to be effective in the treatment of several types of acute and chronic human leukemias, was impregnated in a silicone polymer monolithic disk device for release in vitro in the presence of the antitumor nucleoside N6-(∆2-isopentenyl)adenosine (II) against mouse L-1210 lymphocytic leukemia cells. Although I is ineffective alone against L-1210 cells, controlled release from the polymeric delivery matrix potentiates the antiproliferative effects of II during the midlog phase of growth (48hr). Cytotoxicity is prolonged, leading to total cell death during the stationary phase of growth (96hr). The present study suggests that polymeric delivery systems be used for controlled release of oncologic agents, alone or in combination with inhibitors, especially where lability is a concern.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
