Abstract
Our studies utilizing I'3l-labeled serum albumin (RISA) and S35-sulfate as indicators have shown that the blood brain barrier (BBB) changes produced by head X-irradiation in the rat (10,000 r) were subtle in comparison to other changes such as those after Metrazol-induced seizures and osmotic imbalance (Nair and Roth, 1). In the present study, BBB changes have been further examined under the same irradiation conditions but by employing in addition selected pharmacological indices. This approach has the advantage that, when enhanced pharmacological effects are found in the irradiated animal, the question of whether this enhancement is related to increased penetration by the drug as a result of barrier changes could be answered by measuring the concentration and rate of penetration by the drug. Although pharmacological effects are not necessarily relatable to drug concentration in specific areas, in the above case it may provide additional evidence for altered barrier function. The anticonvulsant drug acetazolamide was chosen for this study for three reasons: (1) It was found (Nair et al., 2) that X-irradiation by itself induced an apparent anticonvulsant effect when tested by the maximal
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