Abstract
Adult male rats were injected s.c. with 0.4 or 4 mg/kg of nickel chloride, sodium selenite, sodium arsenite, antimony chloride, cadmium chloride or mercuric chloride (0.5 or 4 mg/kg) before being given sodium warfarin s.c. (0.75 mg/kg). Only mercuric and cadmium chlorides were found to significantly prolong the prothrombin time. With mercuric chloride, the effect was dose-dependent. The prolongation of anticoagulant response was present when the administration of mercuric chloride preceded (48, 24 and 12 h), was concomitant with, or followed (6 and 12 h), that of warfarin. When mercuric chloride was given at 18, 21 or 24 h after warfarin, prolongation of the prothrombin time was no longer observed.
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