Abstract
Aim: This research work was aimed to formulate Enhancing the solubility of Poorly soluble drug i.e. Fluvoxamine tablets by the solvent evaporation method, Fluvoxamine medicament is a selective serotonin reuptake inhibitor (SSRI) antidepressant agent.
 Purpose: The BCS class II drug Fluvoxamine consist low aqueous solubility and low oral bioavailability, for this reason to improve the biological performance of Fluvoxamine drug by solid dispersion mechanism.
 Methodolgy: The drug Fluvoxamine was formulated by using solvent evaporation technique, solid dispersions of Fluvoxamine were prepared with different carriers in different ratios of PEG 6000 & Mannitol (1:1, 1:2 and 1:3).
 Results: Results of prepared solid dispersions of Fluvoxamine by solid dispersion method Finally by comparing all the formulations, formulation (SF3) containing Fluvoxamine and PEG 6000 (1:3) shows better results.
 Conclusion: Here we concluded that the poorly soluble drug solubility improving by solvent evaporation solid dispersion mechanism, and also developed six Fluvovamine formulations (FDF1-FDF6) during this FDF4 shows maximum (98.9±0.8%) drug release at the end of time.
Highlights
Various BCS class II drugs of oral bioavailability enhanced through the pharmaceutically verified formulation development technologies [1]
Here we concluded that the poorly soluble drug solubility improving by solvent evaporation solid dispersion mechanism, and developed six Fluvovamine formulations (FDF1FDF6) during this FDF4 shows maximum (98.9±0.8%) drug release at the end of time
The Fluvoxamine tablets were prepared with direct compression method [11]
Summary
Various BCS class II drugs of oral bioavailability enhanced through the pharmaceutically verified formulation development technologies [1]. The choosed technologies were Micronization, nanosizing, solid dispersions (SD), Size reduction, cyclodextrins, solid lipid nanoparticles, crystal engineering,These methods were used to improve the oral bio availability of drug molecules [2]. Drug permeability, dissolution rate, first-pass metabolism and, presystemic metabolism, these factors which were influence the oral bioavailability of drugs. Low solubility and low permeability were the main reasons for low oral bioavailability of drugs. Solubility is the major role for other dosage forms like parenteral formulations as well as other routes of dosage forms. Aqueous soluble active pharmaceutical ingredients generally desired, high amounts of drug in order to reach therapeutic systemic plasma concentrations after oral administration [3]
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