Abstract
At the Department of Pharmacology of the S.M. Kirov Military Medical Academy, Saint Petersburg, Russia, a number of chemical compounds with thiourea group was synthesized and studied pharmacologically for some decades. Of them gutimin and amtizol are the most known for pharmacologists. They were the first antihypoxic drugs, passed clinical investigations and were approved for reanimatology practice. Bemithyl (bemaktor, metaprot) was another known drug used in clinical urgent practice as an antihypoxic drug, it was used in earthquake in Armenia (1988), in military practice in Afghanistan etc. Antihypoxic drugs were shown to possess polyvalent pharmacological activity. This review is devoted to original compounds synthesized at the Department of Pharmacology and containing pharmacophor thiourea group in mono-, bi- and tricyclic structures. The antihypoxic activity was revealed in majority of the compounds of this row. The influence of these compounds on physical activity and endurance in different situations has been considered in the article.
Highlights
Of them gutimin and amtizol are the most known for pharmacologists. They were the first antihypoxic drugs, passed clinical investigations and were approved for reanimatology practice. Bemithyl was another known drug used in clinical urgent practice as an antihypoxic drug, it was used in earthquake in Armenia (1988), in military practice in Afghanistan etc
This review is devoted to original compounds synthesized at the Department of Pharmacology and containing pharmacophor thiourea group in mono, biand tricyclic structures
The antihypoxic activity was revealed in majority of the compounds of this row
Summary
ПОВЫШЕНИЕ ФИЗИЧЕСКОЙ ВЫНОСЛИВОСТИ У ЖИВОТНЫХ ПРЕПАРАТАМИ С ТИОМОЧЕВИННОЙ ГРУППИРОВКОЙ (ОБЗОР ЛИТЕРАТУРЫ). Повышение физической выносливости у животных препаратами с тиомочевинной группировкой (обзор литературы) // Обзоры по клинической фармакологии и лекарственной терапии. Кирова на кафедре фармакологии несколько десятилетий плодотворно занимались химией и фармакологией соединений, содержащих тио- и изотиомочевинную группировку в своей структуре. Широко известны фармакологам такие соединения, как гутимин и амтизол, — первые отечественные антигипоксанты, прошедшие клинические испытания, которые зарекомендовали себя в реаниматологической и клинической практике. At the Department of Pharmacology of the S.M. Kirov Military Medical Academy, Saint Petersburg, Russia, a number of chemical compounds with thiourea group was synthesized and studied pharmacologically for some decades. Кирова (ВМА) на кафедре фармакологии несколько десятилетий плодотворно занимались химией и фармакологией соединений, содержащих тио- и изотиомочевинную группировку в своей структуре. Широко известны фармакологам такие соединения, как гутимин и амтизол, — это первые отечественные антигипоксанты, прошедшие клинические испытания и зарекомендовавшие себя в реаниматологической и клинической практике. Другой известный препарат — бемитил (бемактор, метапрот) — широко внедрен в практику здравоохранения, неоднократно находил применение в критических ситуациях: землетрясение в Армении, боевые действия в Афганистане и пр
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