Abstract
The objective of this study was to determine the effect of four levels of local probiotic comparedwith commercial probiotic on immune status of common carp Cyprinus carpio as biologicalcontrol. One handared and eight speciement of Cyprinus carpio average weight of 57.85±0.3g werefed during 42 days at 0.05,0.1,0.5 and 0.75mg local probiotic per Kg diet compared with 2mgcommercial probiotic per Kg diet in comparison with the control group without additive. Thephagocyctic index of blood macrophages, reduction of nitrobluetetrazolium (NBT) by radicaloxegen produce from neutrophils cell ,and alternative complement pathway (ACP) activities wereevaluated. A positive correlation was found between the levels of phagocytosis,nitrobluetetrazolium index and alternative complement pathway activities in blood and the levelof inclusion of local probiotic compared with commercial probiotic and control group.
Highlights
فعبىيت اىَخٌَ و اىنبرة اىشبئع,ً اخخشاه اىْبيخزوبيوحخزاسوىيو, ٍؤشز اىبيعَت:اىنيَبث اىَفخبحيت Introduction The immune system of fish has evolved with both non-specific and acquired immune functions to eliminate invading foreign living and non-living agents [1]
The results indicated that the percentge of phagocytosis and phagocytic index in C. carpio groupT4 using local probiotic was the best (84.2% and 2.72) respectively followed by C. carpio T3,T5,T2 and
Phagocytic activity is responsible for early activation of the inflammatory response before antibody production and plays an important role in antibacterial defenses Phagocytic cells generate reactive metabolites such as superoxide anion, hydrogen peroxide and hypochlorous acid in response to membrane stimulation and these antimicrobial substances, may compromise host responses by inducing oxidative damage [18]
Summary
فعبىيت اىَخٌَ و اىنبرة اىشبئع,ً اخخشاه اىْبيخزوبيوحخزاسوىيو, ٍؤشز اىبيعَت:اىنيَبث اىَفخبحيت Introduction The immune system of fish has evolved with both non-specific (innate immunity) and acquired immune functions (humoral and cell mediated immunity) to eliminate invading foreign living and non-living agents [1]. (2004) [3] demonstrated the benefits of immunostimulants on the fish immune system .The application of immunostimulants in aquaculture is described as an innovative approach to enhance the non-specific defence mechanism of fish to diseases [4]. This approach has the multiple benefit of being effective against a wide range of bacteria and viruses, suitable for many species of fish and easy to apply as it can be administerated orally in feeds. Immunostimulants are naturally inevitable occurring compounds that modulate the non-specific immune mechanisms by enhancing the host resistance against diseases [5]. Many probiotic agents stimulate immune response and diseases resistance, and have a positive effect on fish health [10,11].The present study was planned to enhance innate immunity in common carp Cyprinus carpio using different levels of local probiotic
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