Abstract
5-Methyl-2- d-ribobenzimidazole increases the yield of influenza B virus in the chorioallantoic membrane in vitro. Increased yields are observed both in the membrane and in the medium. In embryonated chicken eggs 9 to 12 days old the yield of virus in untreated cultures decreases with the age of egg, whereas the degree of enhancement in the presence of 5-methyl-2- d-ribobenzimidazole increases. The degree of enhancement is directly proportional to the concentration of compound in the range from 0 to 4 m M. Further increase in concentration is not associated with increased enhancement. Membranes from some eggs may show greater than fifteenfold increase in yield of virus in the presence of the compound. The mean maximal increase in membranes from 10-day eggs is 425%. The degree of enhancement increases on prolonged incubation. 5-Methyl-2- d-ribobenzimidazole does not increase the yield of vaccinia virus in chorioallantoic membrane cultures in vitro. At a concentration of 3.7 m M, 54% inhibition of vaccinia virus multiplication was observed.
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