Abstract
1-Methylnicotinamide, a direct methylation product of nicotinamide, stimulates the DNA synthesis and proliferation of rat liver cells (RLC) in culture at concentrations higher than 20 μM. The effect of nicotinamide, which is a potent inhibitor of DNA synthesis and proliferation, is counteracted by 1-methylnicotinamide. The intracellular NAD concentration decreases within 2 h under 1-methylnicotinamide, whereas it increases in the presence of nicotinamide. The poly(ADP-ribose) synthesizing activity in the isolated nuclei remained unchanged. These results suggest a physiological role of 1-methylnicotinamide in the cell growth through a lowering of intracellular NAD level.
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