Abstract
In an earlier report from our laboratory [ 8], we described some changes in the mechanical activity of rat isolated papillary muscles exposed to therapeutic ultrasound. With ultrasound intensity at 1.0 W/cm 2 (1MHz) we noted a significant depression of resting or diastolic force without a concomitant alteration of the developed force. We attributed this change to nonthermal effects of the irradiation since temperature compensated controls did not show the same effect. Those experiments were performed at a temperature of 26°C and a stimulation rate of 3 pulses/min. In the present experiments, we describe the effects of therapeutic ultrasound on rat isolated papillary muscles stimulated to contract at rates between 6 and 360/min at a temperature of 30°C under both normal and hypoxic-acidotic conditions. In all cases, we induced a significant increase in the developed force of muscles exposed to the ultrasound for a 5 min period.
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