Abstract
The colon can have an absorptive function similar to that of the small intestine after the massive resection of the small bowel. To improve colonic absorptive function, we created a valve in the colon (artificial colonic valve, ACV). ACVs were created in 20 rats that had 80 percent of their small intestine resected, with an observation time of 30 weeks. The ACV rats were compared with those in the non-operated control group, the short bowel syndrome (SBS) group and the colon interposition (CI) group. The ACV rats were much heavier than those in the control group, SBS group and CI group. In terms of histology and the levels of α-amylase and the Na+-dependent bile salt transporter, the absorptive function of the colons before the valves resembled that of the small intestine. The colonic absorptive function was more obvious in ACV rats than in CI rats. An ACV can enhance colonic absorptive function after the massive resection of the small intestine. The colonic absorptive function of ACV rats was better than that of the rats in the CI group.
Highlights
Animal Center for this study were divided randomly into 4 groups
The survival rate of the rats in the colon interposition (CI) group was 80 percent
Distraction enterogenesis has been proven in animal experiments to increase the absorptive area.[6]
Summary
The weights of the rats in all the groups were not significantly different (P > 0.5). The rats in the control group (Group 1) received no operation. The SBS rats in Group 2 had 80 percent of their small intestine/ileocaecal valves and caecums resected. The rats in Group 3 had 80 percent of the small intestine/ileocaecal valves and caecums resected, and an ACV was created in the middle colon (the colon before the valve was 5 cm in length). The rats in Group 4 had 80 percent of their small intestine/ ileocaecal valves and caecums resected, and CI was performed at the same time (the interposed colon has a length of 5 cm). The rats were anaesthetized by the inhalation of halothane. After 30 weeks, the rats were sacrificed with an intra-cardiac injection of 2 ml pentobarbital. The rats were cared for in accordance with the institutional guidelines o
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