Abstract
The blood-brain barrier is a major obstacle that prevents therapeutic drugs or genes being delivered into the central nervous systems. Therefore, it is important to develop enabling enhance the permeability of blood-brain barrier (BBB). So far, we have developed echo-contrast gas (C3F8) entrapping liposomes (Bubble liposomes, BLs) which can be work as a gene delivery tool in the combination of ultrasound (US) exposure. Here, we investigated whether the delivery efficiency of intravenously injected large molecular agents can be induced by the combination of BLs and high-intensity focused ultrasound (HIFU).
Highlights
Background/introduction The blood-brain barrier is a major obstacle that prevents therapeutic drugs or genes being delivered into the central nervous systems
We have developed echo-contrast gas (C3F8) entrapping liposomes (Bubble liposomes, BLs) which can be work as a gene delivery tool in the combination of ultrasound (US) exposure
BLs were injected and right hemispheres were exposed with a 1.0 MHz pulsed high-intensity focused ultrasound (HIFU) (10% duty, 10-60 sec) with different intensities (0.1-1.5 kW/cm2)
Summary
Enhancement of blood-brain barrier permeability by the combination of bubble liposomes and high-intensity focused ultrasound Background/introduction The blood-brain barrier is a major obstacle that prevents therapeutic drugs or genes being delivered into the central nervous systems. It is important to develop enabling enhance the permeability of blood-brain barrier (BBB). We have developed echo-contrast gas (C3F8) entrapping liposomes (Bubble liposomes, BLs) which can be work as a gene delivery tool in the combination of ultrasound (US) exposure.
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