Abstract
SummaryPretreatment of REC cultures for 24 hr with low concentrations of estrogenic and androgenic hormones modified the expression of Ad-12 lytic activity and significantly enhanced the frequency of viral transformation. The augmented effect of the steroid compounds does not appear to be sex-dependent since both male and female REC cultures exhibited enhanced transformation. However, stimulation or inhibition of Ad-12 induced transformation in these in vitro cell systems appears to be dependent on the concentration of hormones employed. The enhancing effect of the sex steroids appears to extend beyond the in vitro transformation state. This is indicated by the markedly increased tumor production in animals implanted with 17-β-estradiol derived transformed cells.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.