Abstract
In this Perspective, we provide an overview of the core concepts around surface-enhanced Raman spectroscopy (SERS) enhancement factors (EFs), including both theoretical and experimental considerations: EF definitions, the distinction between maximum and average EFs, EF distribution and hot-spot localization, EF measurement and its order of magnitude. We then highlight some of the current challenges in this field, focusing on a selection of topics that we feel are both topical and important: analyte-capture onto a SERS substrate, surface-enhanced resonant Raman scattering, orientation/tensorial effects, and nonradiative effects. We hope this Perspective can provide a platform to reflect on the past 50 years of SERS and its future.
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