Enhancement and Inhibition of Microsomal Drug Metabolism

Abstract

Rates of drug metabolism in man and animals can be altered in a variety of ways. For example, it is well-known, that chronic administration of many drugs results in increased rates of microsomal drug metabolism [1]. Conversely, a number of treatments will reduce the rate of drug metabolism. Included are X-irradiation [2], alkylating agents [3], ascorbic acid deficiency [4], alloxan diabetes [5], morphine [6], carbon tetrachloride [7], 3-amino-1,2,4-triazole [8] and p-aminosalicylic acid [9]. In many cases it appears that these treatments serve to produce quantitative reductions in the amount of enzyme protein and, thus, diminish drug metabolism.KeywordsDrug MetabolismAlternative SubstrateDouble Reciprocal PlotAromatic HydroxylationIsonicotinic Acid HydrazideThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.