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Abstract
In this work, we have successfully synthesized a bimetallic (Zinc and Cobalt) Zeolitic Imidazolate Framework (Zn50Co50-ZIF), a class in a wider microporous Metal-Organic Framework (MOF) family. The synthesized nanostructures maintain both water stability like ZIF-8 (solely Zn containing) and charge transfer electronic band in the visible optical spectrum as ZIF-67 (solely Co containing). Crystal structure from XRD, high resolution transmission electron microscopy (HRTEM) followed by elemental mapping (EDAX) confirm structural stability and omnipresence of the metal atoms (Zn and Co) across the nanomaterial with equal proportion. Existence of charge transfer state consistent with ZIF67 and intact ultrafast excited state dynamics of the imidazolate moiety in both ZIF-8 and ZIF-67, is evidenced from steady state and time resolved optical spectroscopy. The thermal and aqueous stabilities of Zn50Co50-ZIF are found to be better than ZIF-67 but comparable to ZIF-8 as evidenced by solubility, scanning electron microscopy (SEM) and XRD studies of the material in water. We have evaluated the photoinduced ROS generation by the mixed ZIF employing dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay. We have also explored the potentiality of the synthesized material for the alternate remediation of methicillin resistant Staphylococcus aureus (MRSA) infection through the photoinduced reactive oxygen species (ROS) generation and methylene blue (MB) degradation kinetics.
Highlights
Treatment of antibiotic resistant infections is a global hazard to human civilization[1] poses an open challenge to the contemporary therapeutic research to combat multi-drug resistant bacteria[2,3]
The indirect antimicrobial effect can be achieved through the use of the nanomaterials as antimicrobial delivery vehicles to successfully deliver them to the infection site[13,14]
The mixed-coordination of Hmim with an initial similar molar ratio of Zn2+ and Co2+ ions used in synthesis, have been denoted as Zn50Co50-Zeolitic imidazolate frameworks (ZIF)
Summary
Treatment of antibiotic resistant infections is a global hazard to human civilization[1] poses an open challenge to the contemporary therapeutic research to combat multi-drug resistant bacteria[2,3]. Depending upon the metal ions and substitution present at the imidazolate linker, ZIF sometime exhibits exceptional thermal, chemical and water stability. The absorbance is plotted against time and nature of the plot suggests relative effectiveness of the ZIF samples as an antibacterial agent.
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