Abstract
Indirect ophthalmoscopy (IO) is the standard of care for evaluation of the neonatal retina. When recorded on video from a head-mounted camera, IO images have low quality and narrow Field of View (FOV). We present an image fusion methodology for converting a video IO recording into a single, high quality, wide-FOV mosaic that seamlessly blends the best frames in the video. To this end, we have developed fast and robust algorithms for automatic evaluation of video quality, artifact detection and removal, vessel mapping, registration, and multi-frame image fusion. Our experiments show the effectiveness of the proposed methods.
Highlights
Hardware improvements yield quickly diminishing returns when gathering useful information from medical images, because the optical components necessary to capture very high-quality scans become prohibitively expensive for many practical applications
This value represents how often ROPTool is clinically valuable and suggests that our mosaicing pipeline improves the diagnostic accuracy of semi-automated Retinopathy of Prematurity (ROP) analysis by almost 20%
We have developed an effective and efficient pipeline for constructing a high quality, large Field of View (FOV) mosaic from a raw video indirect ophthalmoscopy (VIO) video
Summary
Hardware improvements yield quickly diminishing returns when gathering useful information from medical images, because the optical components necessary to capture very high-quality scans become prohibitively expensive for many practical applications. The image processing community has developed several multi-frame image fusion algorithms [1, 2] that generate high-quality imagery from lower-quality imaging detectors. We develop fast and robust multi-frame image fusion algorithms to produce wide Field of View (FOV) and artifactfree images from a large collection of narrow FOV images of varying quality. Important features of the disease include increased diameter (dilation) as well as increased tortuosity (wiggliness) of the retinal blood vessels in the portion of the retina centered on the optic nerve (the posterior pole). Studies have shown that when the blood vessels in the posterior pole show increased dilation and tortuosity (called pre-plus in intermediate, and plus in severe circumstances), this correlates well with the severity of the ROP [4]
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