Abstract
N/A
Highlights
In this ex vivo analysis of transdermal 2%Figure 1 salicylic acid uptake, low-power 1440-nm non-ablative fractional diode laser pretreatment with 320 microscopic treatment zones (MTZ)/cm[2] resulted in greater retention within skin tissue samples compared to untreated controls and the 80-MTZ/cm[2] setting
Retention enhancement following treatment with greater MTZ density did not appear to have an additive effect on overall uptake at 24 hours, supporting the argument that salicylic acid uptake may be predominantly transfollicular
These results may guide the development of treatment protocols for clinical use of non-ablative fractional laser pretreatment to enhance uptake of salicylic acid–containing topicals
Summary
In this ex vivo analysis of transdermal 2%Figure 1 salicylic acid uptake, low-power 1440-nm non-ablative fractional diode laser pretreatment with 320 MTZ/cm[2] resulted in greater retention within skin tissue samples compared to untreated controls and the 80-MTZ/cm[2] setting. Retention enhancement following treatment with greater MTZ density did not appear to have an additive effect on overall uptake at 24 hours, supporting the argument that salicylic acid uptake may be predominantly transfollicular These results may guide the development of treatment protocols for clinical use of non-ablative fractional laser pretreatment to enhance uptake of salicylic acid–containing topicals
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