Abstract
Antheraea pernyi silk fibroin has favorable biocompatibility, good bioactivity and controllable biodegradability, meeting the basic requirements of controlled drug release carriers. Enhancing the negative charge of silk fibroin could further increase the encapsulation and loading efficiency of positively charged drugs. In this study, Antheraea pernyi silk fibroin was chemically modified by methylglyoxal in aqueous solution. The electric charge properties of Antheraea pernyi silk fibroin were examined to characterize the modification, the results indicated that the isoelectric point of Antheraea pernyi silk fibroin decreased from 4.5 to 3.9, and the zeta potential reduced from-11.7 mV to-12.8 mV. Amino acid analysis and 1H-NMR spectra showed that arginine residue of Antheraea pernyi silk fibroin side chain was modified by methylglyoxal for enhancing negative charge of silk fibroin. These results suggested that methylglyoxal-modified Antheraea pernyi silk fibroin could be considered as a potential starting material in loading positively charged drugs.
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