Abstract
Electrospun fiber can be used as a carrier for releasing active ingredients at the target site to achieve the effects of drug treatment. The objectives of this research work were to study suitable conditions for producing electrospun gelatin fiber loaded with crude Curcuma comosa Roxb. extract (CE) and to study antioxidant, anti-tyrosinase and anti-bacterial activities and its freeze–thaw stability as well. To achieve optimal conditions for producing electrospun gelatin fiber, the concentration of gelatin was adjusted to 30% w/v in a co-solvent system of acetic acid/water (9:1 v/v) with a feed rate of 3 mL/h and an applied voltage of 15 kV. The lowest percent loading of 5% (w/v) CE in gelatin nanofiber exhibited the highest DPPH radical scavenging activity of 94% and the highest inhibition of tyrosinase enzyme of 35%. Moreover, the inhibition zones for antibacterial activities against S. aureus and S. epidermidis were 7.77 ± 0.21 and 7.73 ± 0.12 mm, respectively. The freeze–thaw stability of CE in electrospun gelatin nanofiber was significantly different (p < 0.05) after the 4th cycle as compared to CE. Electrospun gelatin nanofiber containing CE also showed the capacity of the release of bioactive ingredients possessing anti-oxidant properties and, therefore, it could potentially be used for face masks.
Highlights
Curcuma comosa Roxb. is a species in the genus Curcuma of the family Zingiberaceae
Electrospun gelatin nanofiber sheets loaded with various concentrations of crude ethanol extract of Curcuma comosa Roxb. rhizome powder (CE) were tested for their antibacterial activity by the disc diffusion method and by the broth dilution method
The suitable conditions for fabricating electrospun gelatin nanofibrous mat loaded with crude ethanol extract of Curcuma comosa Roxb. rhizome powder (CE) were 30% (w/v) gelatin solution in acetic acid/H2 O (9:1 (v/v)) mixed with 5% (w/v) of CE
Summary
Curcuma comosa Roxb. is a species in the genus Curcuma of the family Zingiberaceae. It has been used in traditional folk medicine for the treatment of a wide range of diseases in many Asian countries [1,2]. An electrospun nanofibrous mat exhibited superior properties such as effective drug encapsulation, high drug loading efficacy, wide range of polymers to accommodate compatibility, and the ability to adjust drug releasing level through its high surface to volume ratio [19,20,21] Several polymeric materials such as cellulose [22,23,24], polycaprolactone [25], poly (lactic acid) [26], polyvinyl alcohol [27,28] and gelatin [29,30] have been currently used to encapsulate many drugs or bioactive compounds by electrospinning.
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