Abstract
The purpose of this investigation was to determine whether lyophilization or freeze-drying Aceclofenac could improve the solubility of the medicine, making it more easily dissolved into tablets. The drug aceclofenac is classified as a biopharmaceutical classification system (BCS) class II medicine. The lyophilization process was facilitated by the addition of SLS as an adjuvant, which has the potential to enhance the dissolving rate. Aceclofenac was swiftly released from fast-dissolving tablets by including an appropriate ratio of PVP K-30. Aceclofenac from a lyophilized sample dissolved at a much faster pace than plain aceclofenac in-vitro. The amount of polymer had an effect on the dissolving rate. The dissolving efficiency of the drug and polymer is enhanced at a 1:2 ratio. Therefore, aceclofenac can be effectively dissolved using the lyophilization procedure.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
